Symptoms of NK cell leukemia
summary
Aggressive NK cell leukemia, aggressive NKI for lgll (large granular lymphoblastic leukemia) type 1, for CD3 NK line caused by LGL proliferation, also known as nk-lgll. The number of NK cells was more than 0.40 (40%), and the absolute value was more than or equal to 0.6 × 10 ^ 9 / L for 6 months. Most of them are young people with acute and chronic type. Symptoms of NK cell leukemia? Let's talk about it
Symptoms of NK cell leukemia
NK cell leukemia progressed rapidly with a younger onset age and a median age of 39 years. The initial symptoms were fever, night sweats, weight loss and hepatosplenomegaly. Most patients have bone marrow infiltration, sometimes accompanied by bone marrow fibrosis. Some patients may have gastrointestinal involvement, and rheumatoid arthritis is rare.
Aggressive NK cell leukemia (ankl) originates from the abnormal proliferation of NK cells, and the disease progresses rapidly. Most patients have multiple organ failure in a very short time, and some patients also have the phenomenon of phagocytosis of blood cells, which is very dangerous. The average survival time of ankl patients is only a few months even if they actively receive regular treatment
Some studies have shown that the prognosis of CD56 + acute leukemia is poor no matter how actively treated. Some people think that it may be related to the expression of multidrug resistance gene and P-glycoprotein in normal and malignant NK cells. In addition, the disease is prone to tumor lysis syndrome in the process of combined chemotherapy, causing hyperuricemia, hyperkalemia, hypocalcemia and acute renal failure, aggravating the disease and directly leading to death.
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In a word, NK cell leukemia is a highly aggressive malignant disease, the disease progresses rapidly, patients with multiple organ failure caused by death, there is no effective treatment. Only early diagnosis and prevention of further development of the disease can win time for the survival of patients.
