Can congenital syphilis be cured?

summary

Congenital syphilis, also known as fetal syphilis, is syphilis caused by Treponema pallidum entering the fetal blood circulation through the placenta. The main clinical manifestations of congenital syphilis are skin and mucous membrane damage, hepatosplenomegaly, premature delivery, bone lesions, anemia, jaundice, etc. Can congenital syphilis be cured? Let me talk about it.

Can congenital syphilis be cured?

All infants suspected or diagnosed with congenital syphilis should have cerebrospinal fluid examination before treatment. If cerebrospinal fluid RPR is positive or abnormal (white blood cell count > 5 / rr13 or protein > 500g / L), neurosyphilis should be treated. Penicillin is the most effective drug in the treatment of syphilis. For children without serious complications, the clinical cure rate is nearly 100%. To early, timely and active treatment.

Neonatal period of congenital syphilis treatment: within 7 days after birth, intravenous drip of crystalline penicillin g50000 U / kg, once every 12 hours, then once every 8 hours, a total of 10 days; Or after birth, procaine penicillin 50000 U / kg, intramuscular injection once a day, a total of 10 days. After neonatal period: Penicillin G 50 000 U / kg was injected intravenously every 4-6 hours for 10-14 days.

Serological examination (RPR) and follow-up should be performed at 2, 4, 6, 9 and 12 months after antiviral treatment. Those whose RPR titer did not decrease or increased should be given regular treatment again. The follow-up of this case showed that the early diagnosis of congenital syphilis after birth and adequate treatment with penicillin had a good prognosis. Early diagnosis and regular treatment are effective ways to reduce the incidence rate and mortality of congenital syphilis.

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Early syphilis (primary syphilis, secondary syphilis and early latent syphilis) and late syphilis (except cardiovascular syphilis and neurosyphilis) were treated with 2.4 million U benzylpenicillin intramuscularly once a week for 4 times. Those allergic to penicillin were treated with erythromycin (the babies were given penicillin). If necessary, increase the course of treatment. Doxycycline or tetracycline should not be used.