What is the cause of vitiligo

summary

My mother has vitiligo on her legs. After taking medicine for more than half a year, the color seems to be a little lighter, and the boundary is not clear. Large pieces of vitiligo have been scattered into small pieces. After the treatment of expert system, now the situation is stable, so what is the cause of vitiligo, do you know? Let's talk about the causes of vitiligo.

What is the cause of vitiligo

First, the theory of heredity. Vitiligo can appear in twins and families, indicating that heredity plays an important role in the pathogenesis of vitiligo. Studies have shown that vitiligo has incomplete penetrance and multiple pathogenic loci. The decrease of copper or ceruloplasmin levels in the blood and skin of patients with vitiligo leads to the decrease of tyrosinase activity, which affects the metabolism of melanin.

Second: vitiligo can be combined with autoimmune diseases, such as thyroid disease, diabetes, chronic adrenal insufficiency, pernicious anemia, rheumatoid arthritis, malignant melanoma and so on. The specific antibodies of various organs can also be detected in serum, such as anti thyroid antibody, anti gastric parietal cell antibody, anti adrenal antibody, anti parathyroid antibody, anti smooth muscle antibody, anti melanocyte antibody, etc.

Third: mental factors are closely related to the onset of vitiligo. Most patients have mental trauma, excessive tension, depression or depression at the onset or skin lesion development stage. The degeneration of nerve endings in leukoplakia also supports the neurochemical theory. Trauma, sun exposure and some photosensitive drugs can also induce vitiligo.

matters needing attention

Warm tips: Patients with vitiligo should avoid intense exercise under strong light, so as to avoid excessive fatigue, reduce body resistance, and induce the spread of leukoplakia. Appropriate physical exercise can enhance immunity, vitiligo patients can participate in. Phenols or polyphenols are the intermediates of melanin biosynthesis. Phenols rich diet has certain cytotoxic side effects on melanin, which can inhibit the synthesis of melanin cells, and then affect the treatment of vitiligo patients with skin leukoplakia.