How to treat alcoholic liver

summary

Uncle can be said to be a heavy drinker. He can't even live without alcohol. It's just because he has been drinking for a long time. Recently, he felt liver discomfort. He went to the hospital and was found to have alcoholic liver. Now let me talk about how to treat alcoholic liver.

How to treat alcoholic liver

First: steroids. Alcoholic liver is due to excessive acetaldehyde increased the burden of liver metabolism, resulting in liver injury. Hormone can inhibit the immune damage caused by acetaldehyde and improve the short-term survival rate of severe alcoholic hepatitis. The short-term use of hormone can significantly reduce the mortality. But not all patients with alcoholic liver disease can take hormone drugs, such as upper gastrointestinal bleeding, acute infection, diabetes and so on, these patients can not take hormone drugs.

Second, promote the degradation of extracellular matrix. It mainly refers to drugs with collagenase activity or promoting collagenase activity. This is based on the principle that promoting collagen degradation may reverse the formation of liver fibrosis and develop drugs to promote collagenase activity. At present, the drugs developed include phorbol, cytochalasin B, PDGF and tumor necrosis factor, which can increase or promote the production and synthesis of collagenase.

Third: gene therapy. Gene therapy has been studied in recent years. It has been reported that antisense oligonucleotide (ASO) DNA was used to target 3-t-3 asgr cells with asorpl as carrier. It is concluded that ASOE and ASoC can inhibit most of the mRNA of type I procollagen respectively, which is a good start of gene therapy against fibrosis.

matters needing attention

There are many ways to treat alcoholic liver disease. It is the key and premise to get rid of the bad habit of drinking alcohol. In addition, we can take some steroids appropriately, and we should make a comprehensive judgment according to the specific condition of the patient.