What is the cause of benign chondroblastoma?

summary

Chondroblastoma is one of the diseases with a cure rate of only 10% to 30% in our current life. Although the disease seems to bring few symptoms to the patients, these symptoms are extremely bad for the growth and development of teenagers and other people, So patients and their families should pay more attention. So next, let's have a specific understanding about the etiology of benign chondroblastoma?

What is the cause of benign chondroblastoma?

Gross examination showed that the boundary between chondroblastoma and surrounding cancellous bone was clear. The lesions were blue gray to gray white, with gravel like yellow calcification and necrosis area. The tumor was rubbery. There may be cystic changes in the lesions, most of which have hemorrhagic changes. Chondroblastoma may invade the joint directly or indirectly.

Microscopically, chondroblastoma was characterized by round, oval or polygonal chondroblasts with clear cytoplasm margin and eosinophilic staining. The nucleus is round, oval and kidney shaped, with 1-2 nucleoli. Occasionally, large cells with deep nuclear staining could be seen, but there was no obvious nuclear heteromorphism or pathological mitosis. Multinucleated giant cells can be dispersed in chondroblasts or concentrated in the areas of hemorrhage or necrosis. These giant cells are smaller and smaller than those seen in giant cell tumors. In some cases, chondroblasts and multinucleated giant cells can be lined in hemorrhagic lesions and cystic hemorrhagic spaces, similar to the microscopic findings in aneurysmal bone cysts. It is said that this change occurs in 15% to 25% of chondroblastic tumors.

The histological diversity of chondroblastoma is due to the different stages of the development of the disease. At the beginning, there were more cells in the tumor, gradually appeared necrosis, absorption, repair fibrosis, and metaplasia to cartilage like tissue and bone tissue. The key point of diagnosis is the calcification of cell membrane and bone matrix of some tumor cells, and the disappearance of nuclei to form a special "lattice". The necrotic focus was absorbed and replaced by fibrous tissue or cartilage like tissue. The mature cartilage like tissue can also form hyaline cartilage. If the above changes are mixed together, it will increase the complexity of pathological diagnosis.

matters needing attention

Patients with this disease usually in life to some common sense of this disease to carry out more detailed understanding, for the cause of this disease, patients should pay attention to avoid the preventive measures of this disease, patients should also try to do, usually for other types of diseases should pay attention to timely treatment.