What is the starting point of Sjogren's syndrome

summary

Sjogren's syndrome is a disease that usually occurs between 40 and 50 years of age. In general, the proportion of female patients is relatively large, while the proportion of male patients is relatively small. Children may also have the condition. Now let's talk about the origin of Sjogren's syndrome.

What is the starting point of Sjogren's syndrome

First: autoimmunity: a variety of autoantibodies, such as antinuclear antibody, rheumatoid factor, anti RNP antibody, anti SSA antibody, anti SSB antibody, and hyperglobulinemia, were detected in Sjogren's syndrome patients, which reflected the hyperfunction of B lymphocytes and the low suppression function of T lymphocytes. In addition, the change of T lymphocyte subsets in Sjogren's syndrome, that is, the decrease of inhibitory T cells, reflected the decrease of T lymphocyte subsets Abnormal cellular immunity.

Second: in the research and determination of immune genetics, medical scientists found that HLA-DR3, B8 and Sjogren's syndrome are closely related, and the correlation varies with race, such as Western European people and HLA-B8, DR3, dw52, Japanese people and hla-dr53, which shows that Sjogren's syndrome has genetic tendency.

Third: virus infection: at present, at least three viruses, such as Epstein Barr virus, cytomegalovirus and HIV, are considered to be related to Sjogren's syndrome. Epstein Barr virus can stimulate B cell proliferation and produce immunoglobulin. Some medical experts have detected the main symptoms of Epstein Barr virus and its DNA gene in salivary gland, lacrimal gland and kidney samples of patients with primary Sjogren's syndrome.

matters needing attention

Patients with Sjogren's syndrome usually have a series of adverse symptoms such as dry mouth and dry eyes. And Sjogren's syndrome can be divided into primary Sjogren's syndrome and secondary Sjogren's syndrome. However, the incidence of primary Sjogren's syndrome in China is very low.