How to diagnose early Parkinson's disease

Update Date: 2022-08-10 Source: Network

summary

Recently, grandfather Wu always feels that his speed of action is obviously slower, and sometimes his muscles are stiff for no reason. I'm afraid it's Parkinson's disease. I want to go to the hospital for a specific examination. Now let me tell you how to diagnose Parkinson's disease in the early stage.

How to diagnose early Parkinson's disease

First, SPECT imaging: functional imaging of dopamine transporter (DAT): how dat transports dopamine (DA) is unclear. Dat is mainly distributed in basal ganglia and thalamus, followed by frontal lobe. There is a positive correlation between dat content and the severity of Parkinson's disease. Dat in basal ganglia is decreased, which is very significant in early Parkinson's disease.

Second: brain CT, MRI examination: because Parkinson's disease is a degenerative disease of the central nervous system, pathological changes are mainly in the substantia nigra, striatum, globus pallidus, caudate nucleus and cerebral cortex, so, CT imaging performance, in addition to universal brain atrophy, sometimes visible basal ganglia calcification. In addition to ventricular enlargement and other signs of brain atrophy, T2 weighted images often have multiple hyperintense spots in basal ganglia and white matter.

Third: auxiliary examination: high performance liquid chromatography (HPLC) can detect the decrease of HVA (homovanillic acid) content in cerebrospinal fluid and urine, brain CT can have sulcus widening and ventricle enlargement. In addition to this examination method, it also includes excluding Parkinson's syndrome caused by encephalitis, cerebrovascular disease, poisoning and trauma, and distinguishing it from hysterical, tension and senile tremor.

matters needing attention

Parkinson's disease is a disease that often occurs in the elderly, the disease is very harmful, serious, and even can lead to patients can not take care of themselves, in addition to some symptoms, there is a common clinical examination method, the above introduces three.