What effect does antithrombin 3 low have?

summary

Antithrombin 3 is a very important anticoagulant protein in human body. If antithrombin 3 is low, it can weaken the anticoagulant effect of blood, and lead to myocardial infarction, angina pectoris, cerebrovascular disease, pregnancy and so on. Antithrombin 3 on the low side is caused by heredity. What's the effect of antithrombin 3 on the low side? Next, I'd like to share my views with you.

What effect does antithrombin 3 low have?

Hereditary at Ⅲ deficiency is an autosomal dominant hereditary disease. The prevalence rate of the disease is about 1 / 5000. Most of the patients are 10-25 years old. Venous thrombosis often occurs after surgery, trauma, infection, pregnancy or postpartum, and can occur repeatedly. The bioactivity and antigenicity of at Ⅲ in the plasma of CRM - patients were about 50% of that of normal people. There are many types of structural and functional abnormalities in CRM + at Ⅲ. The common performance is that the affinity of CRM + for heparin is reduced, and the inactivation ability of CRM + for serine protease is significantly weakened.

At Ⅲ synthesis decreased in liver diseases, liver dysfunction, mainly in liver cirrhosis, severe hepatitis, advanced liver cancer, often associated with the severity of the disease, accompanied by thrombosis. Increased at Ⅲ loss: seen in nephrotic syndrome.

If thrombin activity is low, it may be difficult to stop bleeding during labor. Its function is similar to that of platelets, both of which make blood coagulate and stop bleeding. But if it's too high, it can form a thrombus. Antithrombin 3 low serious words on pregnant women and fetuses are affected.

matters needing attention

The samples were anticoagulated with 0.109 mol / L sodium citrate instead of heparin. Pay attention to establish good living habits, drink more water, supplement enough vitamins, fresh fruit, try to eat less junk food.