What is organophosphorus poisoning

summary

I believe that you must have experienced the event of organophosphorus poisoning in your daily life. Organophosphorus can be a drug or a pesticide poison. People often get poisoned because of this ingredient. Now let's popularize the science of organophosphorus poisoning.

What is organophosphorus poisoning

First: organophosphate pesticides (referred to as organophosphorus pesticides) are volatile and have garlic odor. It is usually stable in acidic environment and easy to decompose in case of alkali. It can be absorbed through skin, respiratory tract and digestive tract, and quickly distributed to all tissues and organs of the whole body with blood flow. It is stored in adipose tissue, and the concentration of fat can reach 20-50 times of blood concentration.

Second, organophosphorus pesticides mainly form phosphorylated Che through the combination of electrophilic phosphorus and Che, inhibit the activity of Che, especially the activity of acetylcholinesterase (AChE), make ache lose the ability to decompose acetylcholine, and acetylcholine accumulates in the physiological effect site, resulting in a series of hyperactivity of cholinergic nerves.

Third, some organophosphorus can bind with the specific protein net enzyme in brain and spinal cord to make NTE aging. That is to say, organophosphorus can inhibit the activity of NTE in axonal, cause energy metabolism disorder in axonal transport, axonal degenerative changes, secondary demyelinating lesions, and cause delayed neurotoxicity.

matters needing attention

Organophosphorus can play its greatest role as long as it is used properly, but it is often poisoned because it is taken by mistake or absorbed into the skin, especially for some migrant workers.