What are the factors that affect the success rate of bone marrow transplantation

summary

Bone marrow transplantation, also known as hematopoietic stem cell transplantation, refers to the process of intravenous infusion of hematopoietic stem cells from peripheral blood, umbilical cord blood, or bone marrow. Let's talk about the factors that affect the success rate of bone marrow transplantation.

What are the factors that affect the success rate of bone marrow transplantation

First, the timing of BMT: the first remission of BMT is better than the second remission. Brotint et al. (1988) compared the BMT results of the first remission and the second remission in Al patients. BMT should be performed in the first complete remission in patients with acute leukemia.

Second, the nature of the disease itself: the relationship between BMT efficacy and classification is not clear, it seems that AML efficacy is better than all. For all patients, the following indicators can be considered as high-risk factors: age less than 2 years old or more than 15 years old, peripheral white blood cells > 50 × 109 / L at the time of initial diagnosis, central nervous system leukemia, and high-risk factors;

Third: the age and general condition of the patients: the older the patients are, the worse the organ function is, and the more likely the complications, especially GVHD, will occur after BMT. Therefore, it is cautious to carry out allogeneic bone marrow transplantation for patients over 45 years old. Generally, allogeneic bone marrow transplantation is not carried out for patients over 50 years old.

matters needing attention

Bone marrow transplantation is a treatment for patients with blood diseases. Bone marrow transplantation may be accompanied by various complications, including early complications and late complications. However, with the development of bone marrow transplantation, the curative effect of surgery has been gradually stable.