vitamin D intoxication

summary

Vitamin D poisoning is one of the iatrogenic diseases. It is mainly due to the misdiagnosis and excessive use of vitamin D preparations in the prevention and treatment of rickets, such as cod liver oil, vitamin D2 (ossitol), vitamin D2 (cholecalciferol or choleretin) and vitamin D colloidal calcium. Let's talk about vitamin D poisoning

vitamin D intoxication

1. The earliest symptoms are loss of appetite, even anorexia, irritability, crying, low spirit, and low fever. There may also be hyperhidrosis, nausea, vomiting, diarrhea or constipation, gradual emergence of thirst, frequent urination, nocturia, occasional dehydration and acidosis. Older children can report headache, blood pressure can rise or fall, heart can be heard and systolic murmur, ECG ST segment can rise, sometimes mild anemia.

2. Severe cases may appear depression, hypotonia, dyskinesia, even coma, convulsion, renal failure, etc. Urine specific gravity is low and fixed, urine protein is positive, cell increases, also can have tubular. Long term chronic poisoning can lead to calcification of bones, kidneys, blood vessels and skin, affect physical and intellectual development, and even cause death due to renal failure. Vitamin D poisoning in early pregnancy can cause fetal malformation.

3. Control infection and correct dehydration acidosis. In general, it takes a long time for the patients to recover after the above treatment. The blood calcium level will return to normal after 2-3 months, and the recovery of renal function can be delayed for 18 months.

matters needing attention

The dosage of VitD used in the past should be inquired in detail before shock treatment. Most of the poisoning cases are on the basis of long-term oral administration of cod liver oil in large quantities, and the poisoning symptoms are more likely to appear after D2 or D3 injection, so the indications must be mastered before large dose injection.