Symptoms of toluene poisoning

summary

Toluene, C6H5CH3, is a colorless, non corrosive, sweet and aromatic liquid. Insoluble in water, soluble in ethanol, ether and acetone. Opportunities for industrial exposure to toluene include: coal tar fractionation or petroleum cracking, as solvent or diluent in spray paint, coating, rubber, leather, printing and other industries, as well as in the manufacture of explosives, pesticides, benzoic acid, dyes, synthetic resins and polyester, etc., in addition, it can also be used as a participating component in aviation gasoline. Let's talk about the symptoms of toluene poisoning

Symptoms of toluene poisoning

It can stimulate the skin and mucous membrane and anesthetize the central nervous system at high concentration. Industrial products often contain impurities such as benzene, which may have toxic effects at the same time. Toluene was mainly distributed in fat rich tissues, with adrenal gland, brain, bone marrow and liver as the most.

A small amount was excreted through the lung in its original form; 80-90% of them were oxidized to benzoic acid and combined with glycine to form hippuric acid, which was excreted in urine; A small amount of benzoic acid combined with glucuronic acid was excreted in urine. The concentrations of MLC, MLD and MLD were 300 ppm, 200 ppm and 50 mg / kg respectively. The content of hippuric acid in urine of normal people varies with different dietary varieties and absorption, and individual differences are large, so the content of hippuric acid in urine can not be used as an absorption index and diagnostic index.

Acute poisoning: there are dizziness, headache, nausea, vomiting, weakness of limbs, blurred consciousness, faltering gait after inhaling high concentration steam. In severe cases, there are agitation, convulsion or coma, accompanied by eye and upper respiratory tract irritation symptoms, conjunctival and pharyngeal congestion. The symptoms of pneumonia, pulmonary edema, pulmonary hemorrhage and anesthesia may appear after direct inhalation of liquid.

matters needing attention

Those who inhale high concentration steam shall leave the site immediately and go to fresh air place. Patients with symptoms were given oxygen inhalation, and the changes of the disease were closely observed. Symptomatic treatment. Glucuronic acid can be used. Attention should be paid to the prevention and treatment of brain edema when conscious disturbance or convulsion occurs. Adrenaline should not be used if the heart is still beating.