What reason is sulfonamide drug allergy?

summary

Sulfonamides are synthetic antibacterial agents, which have been used in clinic for nearly 50 years. They have the advantages of broad antibacterial spectrum, stable properties, simple use, and no food consumption. Especially after the discovery of trimethoprim (TMP) in 1969, the combination of TMP and sulfonamides can enhance the antibacterial effect and expand the scope of treatment. Therefore, although a large number of antibiotics came out, sulfonamides are still important chemotherapeutic drugs. What reason is sulfonamide drug allergy? Let's talk about it

What reason is sulfonamide drug allergy?

First of all, some drugs with similar structure to sulfonamides should be used with caution because of drug cross allergy, so as to avoid adverse reactions similar to sulfonamides. Among these drugs, sulfonylureas are the first to bear the brunt. Sulfonylureas are one of the first choice drugs for patients with type 2 diabetes mellitus. They are prone to cross allergic reactions with sulfonamides because they contain a group similar to sulfonamides - p-aminosulfonamides. The varieties include gliclazide (dameikang), glibenclamide (glibenclamide), glipizide (ruiyining), Gliquidone (tangshiping), glimepiride (amoril), etc.

The second is the commonly used thiazides and thiazide like diuretics in patients with hypertension, especially in elderly patients with hypertension, such as hydrochlorothiazide (double gram), indapamide (shoubishan, natril), loop diuretics such as furosemide, etc. bumetanide also has sulfonamide group (so2nh2) at the 7th position of chemical structure, so it will have cross allergy with sulfonamides and should be avoided as far as possible.

It should also be noted that some compound preparations containing the above drugs should also be avoided. Such as antihypertensive drugs: Losartan Potassium hydrochlorothiazide (haijieya), irbesartan hydrochlorothiazide (anbonuo), valsartan hydrochlorothiazide (fudaiwen), hypoglycemic drug Xiaoke pill contains glibenclamide.

matters needing attention

No matter what kind of drug allergy (sulfanilamide or penicillin), you'd better pay special attention to it when you see a doctor in the future, inform the doctor of the allergy history in advance, and carefully read the contraindications in the manual before taking medicine, remember!