What causes Parkinson's disease

summary

A few days ago, the father of a colleague in the company went to the hospital for examination because he was often stiff. He was diagnosed with Parkinson's disease, but his family didn't understand what Parkinson's disease was and how it was caused, so they inquired about the relevant information on the Internet. Now let's take a look at what causes Parkinson's disease.

What causes Parkinson's disease

First, the etiology of idiopathic Parkinson's disease is still unknown. Some degenerative diseases of the central nervous system with Parkinson's disease symptoms, mainly in different parts of the central nervous system degeneration, there are other clinical characteristics, so it can be called symptomatic Parkinson's disease, such as progressive supranuclear paralysis, striatal substantia nigra degeneration and olivopontine atrophy. Clinically known as Parkinson's syndrome.

Second, Parkinson's disease mainly occurs in the middle-aged and elderly people, and rarely occurs before 40 years old, suggesting that aging is related to the onset of Parkinson's disease. It was found that the activity of dopaminergic neurons, tyrosine oxidase and dopa decarboxylase in substantia nigra and the level of dopamine neurotransmitter in striatum decreased with age. However, only a few elderly people suffer from this disease, which indicates that physiological dopaminergic neuron degeneration is not enough to cause the disease, and aging is only the predisposing factor of this disease.

Third, it is generally believed that Parkinson's disease is not a single factor, but a variety of factors may be involved. Genetic factors can increase the susceptibility to the disease. Only under the interaction with environmental factors and aging, oxidative stress, mitochondrial failure, calcium overload, excitatory amino acid toxicity, apoptosis, immune abnormalities and other mechanisms can lead to a large number of degeneration and loss of dopaminergic neurons in substantia nigra.

matters needing attention

In short, at present, the cause of Parkinson's disease is not very clear, but it mostly occurs in middle-aged and elderly people. It is suggested that if you find that you are not feeling well, you must go to see a doctor in time for regular treatment, and don't miss the best treatment time because you don't know it for a moment.