Can late fungal meningitis be cured?

summary

Fungal meningitis is an inflammation caused by fungal invasion of meninges, which often coexists with infection of brain parenchyma. The incidence rate of fungal infection in central nervous system is increasing as antibiotics, hormones, immunosuppressive drugs, especially large doses and long term applications after organ transplantation, increased AIDS incidence and increased number of animal feeding families. Let's share my experience with you.

Can late fungal meningitis be cured?

(1) Amphotericin-B is still the first choice in clinic. Each dose is 0.1mg ~ 0.25mg/kg, diluted with water for injection or 5% glucose solution (not diluted with normal saline, so as to avoid precipitation) to 0.1mg/ml, then slowly drip once a day or every other day, and gradually add to 1mg / kg each time according to the situation.

At the same time, intrathecal injection (diluted with cerebrospinal fluid and added appropriate amount of dexamethasone 1mg) once every other day, 0.1mg for the first time, and then gradually added to 0.5mg/time according to the situation. Generally, the treatment lasted for 6 weeks. If the patient's condition requires and permits, the course of treatment can be appropriately extended until the clinical symptoms basically disappear and the cerebrospinal fluid examination is normal, so as to ensure the curative effect and prevent recurrence. If necessary, 5-fluorouracil (600 mg ~ 1.2 g / day, taken in batches) can be added to enhance the curative effect, and the course of treatment can be longer than amphotericin-B alone.

The dosage of amphotericin-B cholesterol complex for adults and children was 3 ~ 4mg / kg a day, once a day. At the same time, 5% glucose solution was added to dilute to 0.6mg/ml, and intravenous drip was given at the rate of 1mg / kg per hour. Before the first administration, a small dose of 5mg / 10ml should be given intravenously for more than 15-30 minutes. After the infusion, observe for 30 minutes. If the patient adapts, the drug can be given formally. The infusion time should last for two hours; If it is intolerable, the administration time should be extended, and each time should last more than 2 hours. To ensure safety.

matters needing attention

In daily life, eat more fruits and vegetables, keep optimistic mood, pay attention not to fatigue, pay attention to the recovery of the body, in addition, if there are any symptoms should go to the hospital for examination, and corresponding treatment, these are to actively do.