What is the cause of IgA nephropathy?

summary

The full name of IgA nephropathy is autoimmune nephropathy, which is a common disease in nephrology. It refers to the primary glomerulopathy with IgA deposition in glomerular mesangial area, or with other immunoglobulin deposition in glomerular mesangial area. Its clinical manifestations are: repeated paroxysmal gross hematuria or microscopic hematuria, accompanied by varying degrees of proteinuria, some patients can have severe hypertension or renal insufficiency because the condition is not controlled. According to statistics, the causes of IgA nephropathy are as follows.

What is the cause of IgA nephropathy?

Infected. Infection is another common cause of IgA nephropathy. If you ask about the history in detail, many patients will have symptoms of prodromal infection, such as cold, tonsillitis, fever and so on. Most patients do not control the infection in time and go to the hospital when they have hematuria.

The glomerular mesangial area precipitated a lot of immune complexes. There are a lot of immune complexes in the glomerular mesangial region of patients with IgA nephropathy. The main immune complex is IgA, which has a high affinity with the glomerular mesangial cells of patients with IgA nephropathy. The combination of IgA and mesangial cells can lead to the phenotypic transformation of renal intrinsic cells and lead to the occurrence of the disease.

Inflammatory response of mesangial cells. Many patients are initially induced by inflammation IgA deposition, when the patient onset, the renal glomerular mesangial cells are stimulated by inflammatory damage, and produce inflammatory factors, which lead to a large number of immune complexes precipitated in the patient's kidney, and eventually lead to the occurrence of the disease.

matters needing attention

IgA nephropathy is not terrible, usually should pay attention to appropriate rest, avoid strenuous activities, in stable condition need appropriate exercise, enhance disease resistance, avoid cold, reduce the chance of infection. In terms of diet, we should mainly eat light diet, eat more vegetables, fruits and high-quality high protein food, fast spicy, fatty, thick taste, moldy products and pickled products, and avoid tobacco and alcohol.