Symptoms of fetal osteogenesis imperfecta

summary

Some people are prone to fracture and abnormal growth of bone in their life. They only find that they are caused by osteogenesis imperfecta after going to the hospital for examination. Many people have not heard of osteogenesis imperfecta, but we will be more familiar with brittle bone disease, which belongs to the same disease. So the symptoms of fetal osteogenesis imperfecta tell us.

Symptoms of fetal osteogenesis imperfecta

In fact, patients with osteogenesis imperfecta have normal fertility, so it does not affect people to have children. However, osteogenesis imperfecta is hereditary. If patients want to have children, they should first consider that the fetus may also have osteogenesis imperfecta. Because osteogenesis imperfecta is a disease caused by a gene mutation in the patient's body, most of it will be inherited during pregnancy, and osteogenesis imperfecta is a dominant inheritance. If one of the parents is sick, the probability of the child suffering from osteogenesis imperfecta is about half.

If the patient insists on having a baby, the only way is to strengthen the prenatal examination. If the fetus also has osteogenesis imperfecta in its genes, it can be seen when the mother is 16 weeks pregnant. At the time of prenatal examination, we should strengthen the screening. At this time, we may also need to do amniotic fluid puncture and DNA test. If it is caused by congenital osteogenesis imperfecta, the doctor will recommend termination of pregnancy. Patients should also go to experienced hospitals for prenatal examination to avoid omission.

Osteogenesis imperfecta is actually caused by genetic variation in patients. This gene determines the quality of type I collagen, which exists in people's bones, muscles, fascia, ligaments and dentin. If there is a quality problem, these tissues will have lesions. If the quality of type I collagen is not good, the most direct impact is osteogenesis imperfecta.

matters needing attention

The main cause of osteogenesis imperfecta is the mutation of genes in the body, which leads to the decrease of collagen content in the body of patients, thus causing the occurrence of the disease.