What are human hepatoma cell lines
summary
Some time ago, my uncle felt that he didn't have any appetite. He didn't want to eat at all. He was losing weight day by day. When he went to the hospital, he was found to have liver cancer. He felt that the sky was going to collapse. Now let me talk about the human liver cancer cell lines.
What are human hepatoma cell lines
First, HCC cell lines were derived from primary liver cancer tissues, and their biological characteristics were not changed during the establishment of the lines. Most of the early established cell lines belonged to this category. They had some common points, such as AFP positive, and they could secrete some plasma proteins, but there were also some obvious differences.
Second, the tumorigenicity of PLC / PRF / 5 and HepG2 was poor in nude mice, while the success rate of QGY-7703 and SMMC-7721 xenotransplantation was 100%. PLC / PRF / 5 could detect HBsAg, while HepG2 did not contain HBV. Three human hepatoma cell lines showed that HBV could cooperate with AFB1 to induce hepatocarcinogenesis. Hepatitis C virus (HCV) is an important pathogenic factor of liver cancer. A human hepatoma cell line can successfully translate HCV RNAs produced by recombinant adenovirus.
Thirdly, human hepatoma cell line can be used to study the mechanism of drug action. For the study of hepatitis virus, hepatitis virus can be integrated into human liver cancer cell lines. By detecting some indicators, we can study the pathogenesis of hepatitis and provide theoretical basis for hepatitis vaccine and drug therapy.
matters needing attention
Hepatoma cell lines are derived from primary liver cancer tissues, which are complex in content and have intuitive reflection on liver cancer cells. They are often used in the research of liver cancer treatment in medicine, which are more and more extensive and accurate, and their application is also improved very quickly. They are expected to make a great contribution to the treatment of diseases.
