How is acrosclerosis treated?

Update Date: 2021-07-27 Source: Network

summary

Acrosclerosis syndrome is also known as systemic scleroderma and progressive systemic sclerosis. The disease is a diffuse lesion of connective tissue, characterized by inflammatory, fibrous and degenerative changes with vascular lesions. It mainly involves skin (scleroderma), synovium and some internal organs (such as esophagus, intestine, heart, lung, kidney, etc.).

How is acrosclerosis treated?

Abnormal metabolism of connective tissue the disease has a wide range of connective tissue lesions. Fibroblast culture showed that the activity of collagen synthesis was significantly increased, and fibronectin gene mutation was found, leading to abnormal metabolism of connective tissue and the occurrence of PSS. Genetic and environmental factors the disease has obvious family history, which may be related to HLA-DR3, DR6, c4null genes.

Infection factors many patients often have acute infection before onset, such as sinusitis, angina, tonsillitis, pneumonia, scarlet fever and so on. Paramyxovirus like inclusion bodies were detected in the striated muscle and kidney. Many cytokines can regulate the expression of collagen components. Such as TGF beta; It can not only regulate the extracellular matrix, but also affect other cytokines, including IL-1 beta TNFalpha; 1. PDGF, basic fibroblast growth factor, etc.

Acral ulcer: it is an important complication of systemic scleroderma. Persistent and recurrent ulcer can cause severe pain, infection, gangrene, dysfunction and decline of quality of life, which brings great pain to patients. Because of this, the research on acral ulcer of scleroderma has become a hot topic in recent years. Limb ischemia: symptoms caused by insufficient blood supply at the end of limbs. The diagnosis can be made by physical examination.

matters needing attention

1. Keep warm, avoid cold, quit smoking, alcohol, massage, wax therapy, diathermy, etc. 2. Corticosteroids of the upper gland are only effective for early skin edema and myositis. 3. Closed therapy: add 150 mg procaine into 500 ml 5% glucose solution, intravenous drip, once a day or every other day, gradually increase the dose of procaine, but the maximum dose is not more than 1 g / D, 10-15 times is a course of treatment.