Can Wegener's granulomatosis be treated?

summary

Granulomatous vasculitis, formerly known as Wegener's granuloma, is a kind of necrotizing granulomatous vasculitis, belonging to autoimmune diseases. The disease involves small arteries, veins and capillaries, occasionally large arteries. The pathological vascular wall is characterized by inflammation, which mainly invades the upper and lower respiratory tract and kidney. It usually starts with local and focal granulomatous inflammation of nasal mucosa and lung tissue, and then turns out to be diffuse necrotizing granulomatous inflammation of blood vessels. The clinical manifestations are nasal and paranasal sinusitis, Lung disease and progressive renal failure can also involve arthritis, skin, heart, nervous system and ear. Let's take a look at the following.

Can Wegener's granulomatosis be treated?

First: the male is slightly more than the female, from children to the elderly can be onset, recently reported in the age range of 5-91 years old onset, but more middle-aged people, 40-50 years old, is the high incidence age of the disease, the average age of 41 years old. The mortality of untreated GPA can be as high as 90%. The prognosis of GPA can be significantly improved after treatment with technology and immunosuppressant.

Second: the majority of patients with upper respiratory tract disease as the first symptom, usually the performance is continuous runny nose, and increasing, runny nose, can come from the secretion of nasal sinuses, and lead to upper respiratory tract obstruction and pain. Accompanied by nasal mucosa ulcer and scab, epistaxis, bloody saliva, sinusitis can be mild, severe GPA septal perforation, nasal bone destruction, saddle nose.

Third: granulomatous vasculitis, general symptoms, can be slow onset, lasting for a period of time, can also be manifested as rapid progressive onset, the initial symptoms include fever, fatigue, depression, NACHA weight loss, joint pain, night sweats, urine color changes and weakness, of which fever is the most common, fever is sometimes caused by bacterial infection of the paranasal sinuses.

matters needing attention

Lung involvement is one of the basic characteristics of the disease, about 50% of the patients at the onset of both lung performance, a total of more than 80% of the patients in the whole course of the disease, lung lesions, chest tightness, shortness of breath, cough, hemoptysis and pleurisy are the most common symptoms, and pulmonary shadow.