What is the mechanism of organophosphorus poisoning

summary

In daily life, when some farmers spray pesticides on crops, the organic phosphorus will enter the respiratory tract of the human body, causing skeletal muscle weakness and poisoning. Some people will drink pesticides to poison themselves. Now let's talk about the mechanism of organophosphorus poisoning.

What is the mechanism of organophosphorus poisoning

First, organophosphorus pesticides are widely used and the largest amount of pesticides in China. It mainly includes dichlorvos, parathion, phorate, internal absorption of phosphorus, dimethoate, trichlorfon, malathion, etc. Acute organophosphorus pesticide poisoning refers to a series of injuries mainly caused by nervous system damage after a large number of organophosphorus pesticides enter the human body for a short time. Clinically, it mainly includes cholinergic excitement or crisis in patients with acute poisoning, followed by intermediate syndrome and delayed peripheral neuropathy.

Second: after entering the body, organophosphorus poisons quickly combine with cholinesterase in the body to produce phosphorylated cholinesterase, which makes cholinesterase lose the function of hydrolyzing acetylcholine, resulting in the accumulation of cholinergic neurotransmitters, acting on cholinergic receptors, resulting in serious neurological dysfunction, especially respiratory dysfunction, thus affecting life activities. The M-like effect caused by parasympathetic nerve excitation makes a large number of glands secrete in patients' respiratory tract, causing severe pulmonary edema and aggravating hypoxia. Patients may die of respiratory failure and hypoxia.

Third, AOPP can also cause cardiac damage, even sudden cardiac death. The reason may be toxic myocarditis caused by direct damage to the heart, at the same time, the sympathetic and parasympathetic nerve dysfunction in patients with AOPP, resulting in arrhythmia. Results in patients with heart rate is too fast and blood supply is insufficient, at the same time, cardiac oxygen consumption increases, leading to myocardial ischemic damage, the stability of ECG activity is affected, so it is prone to malignant arrhythmia, and even sudden death.

matters needing attention

The above is a brief introduction to the mechanism of organophosphorus poisoning. In fact, it is harmful to human body through respiratory tract and skin, which will seriously affect human life and health. And the toxicity is particularly strong. I hope people should pay special attention when contacting with organophosphorus.