Erythema palmoplantar keratosis symptom map?

summary

Palmoplantar keratosis is a hereditary skin disease characterized by hyperkeratosis of palms and feet, so it is also called hereditary palmoplantar keratosis. It is also the general name of palmoplantar keratosis. It belongs to autosomal dominant inheritance and has a clear family history. Palmoplantar keratosis is a kind of autosomal dominant genetic disease with obvious familial characteristics, which can be passed down from generation to generation or terminated after several generations. No positive family history can be traced back.

Erythema palmoplantar keratosis symptom map?

It can occur from childhood, or in childhood or adolescence, but all have family history. The disease can also be symptomatic, occurring in follicular keratosis and pityriasis rubra. The disease cannot be cured because of heredity.

Palmoplantar keratosis is characterized by symmetry, diffuse keratosis and hypertrophy of palms and soles. Most cases begin to develop in infants. It is pale yellow due to thick skin horns. General patients often accompanied with hyperhidrosis. As a result of keratosis, hypertrophy, winter prone to chaps, the most serious type is destructive palmoplantar keratosis. Because of severe keratosis, hypertrophy and proliferation, resulting in foot deformity and disability. The patients with palmoplantar keratosis can be accompanied by uneven surface, lack of luster, or even with other congenital malformations.

Patients with hereditary diseases should try their best to find other people to get married in order to reduce the probability of genetic diseases. Retinoic acid derivatives should be taken for treatment. After topical application of retinoic acid ointment, the patient's condition was alleviated and improved, but relapsed immediately after drug withdrawal. Gene therapy can be used in the future.

matters needing attention

A hyperkeratosis, B granular layer thickening, C spinous layer thickening, part of papilloma like changes, D superficial dermal blood vessels around sparse lymphocyte infiltration, e epidermolytic palmoplantar keratosis tissue image is the same as epidermolytic hyperkeratosis ichthyosis, f punctate palmoplantar keratosis, the keratin layer can be seen in the dense column of bad keratosis, hyperkeratosis area under the germinal layer of cup depression, There was no inflammation in the dermis.