What causes high creatinine

summary

In my daily life, I pay more attention to maintenance, but recently I went to the hospital for physical examination and found out that the creatinine is high. While the doctor treated me, he also told me about what causes high creatinine. Now I will tell you about the causes of high creatinine.

What causes high creatinine

Reason 1: for creatinine, in muscle, creatine mainly forms creatinine slowly through irreversible non enzymatic dehydration reaction, which is then released into the blood and excreted with urine. Therefore, serum creatinine is closely related to the total amount of muscle in the body and is not easily affected by diet and urine volume.

The second reason: the high serum creatinine is due to the phenotypic transformation of the damaged intrinsic cells of the kidney after the kidney is invaded by various causes, which leads to the formation of pathological changes and stimulates the transformation of fibroblasts into myofibroblasts in the kidney.

The third reason: due to the continuous damage of the kidney, the function of excreting waste is reduced, resulting in the accumulation of creatinine and other toxins in the body, resulting in the increase of creatinine and urea nitrogen in the blood, the decrease of creatinine in the urine, and the decrease of double kidney filtration rate. At the same time, patients will have high blood pressure, high edema and other physical symptoms.

matters needing attention

For patients with high creatinine, food therapy can be used for remission treatment. The normal upper limit of serum creatinine is about 100 μ molgl. Renal patients in clinical examination will appear in the fluctuation of creatinine, performance for blood creatinine is higher than normal, and urine creatinine is lower than normal.