How to treat corneal endothelial cell dystrophy?

summary

It is a general term for a series of primary progressive keratopathy related to familial inheritance. Most of the cases are autosomal dominant; The primary lesion is cornea, rarely accompanied by other ocular or systemic diseases; Most of the patients began before the age of 20; Most of them invaded the center of cornea and their eyes were symmetrical; The course of disease was slow, and there was no neovascularization in the lesion area; At first, only one layer of cornea was invaded; In the late stage, it can affect the adjacent layers, even the whole cornea; Drug treatment was ineffective. Corneal transplantation is feasible for patients with poor vision.

How to treat corneal endothelial cell dystrophy?

1. Corneal epithelial basement membrane dystrophy: after 30 years old, recurrent epithelial erosion. There were many gray plaques, tiny oil drop cysts and fingerprint opacity in the central epithelial layer. 2. Granular dystrophy: the corneal epithelium is rough, there is a clear boundary of gray white turbid block in the central anterior stromal layer, and there is diffuse turbidity between the turbid blocks in the late stage, which seriously affects the vision. 3. Fuchs corneal endothelial dystrophy is more common in women than in middle-aged and old people. The degeneration and loss of corneal endothelium leads to decompensation and epithelial bullous degeneration.

Diagnosis basis 1. Family genetic history. 2. Different degrees of corneal epithelial bullae, stromal opacity and endothelial loss. 3. Bilateral symmetry, no new blood vessel invasion.

Treatment principle 1. Early symptomatic treatment. 2. Corneal transplantation was performed in patients with severe visual impairment in late stage. Mild cases can be treated symptomatically, usually with hypertonic agents or wear soft contact lenses, and use antibiotics to prevent infection. 2. The patients were treated with systemic medicine and supportive treatment.

matters needing attention

Most of the patients began before the age of 20; Most of them invaded the center of cornea and their eyes were symmetrical; The course of disease was slow, and there was no neovascularization in the lesion area; At first, only one layer of cornea was invaded; In the late stage, it can affect the adjacent layers, even the whole cornea; Drug treatment was ineffective. Corneal transplantation is feasible for patients with poor vision.