Symptoms of biliary cirrhosis?

summary

Biliary cirrhosis is caused by biliary obstruction and cholestasis, which is divided into primary biliary cirrhosis (PBC) and secondary biliary cirrhosis. The latter is caused by long-term obstruction of extrahepatic bile duct. It is generally believed that primary biliary cirrhosis is an autoimmune disease. Clinically, remission and deterioration occur alternately, often accompanied by other autoimmune diseases? Now let me tell you something.

Symptoms of biliary cirrhosis?

The common cause is obstruction of bile duct system, such as cholelithiasis, tumor (carcinoma of pancreatic head, carcinoma of Vater's ampulla) and so on. In children, congenital atresia of extrahepatic biliary tract is the main cause, followed by choledochal cyst and biliary cirrhosis. Complete occlusion of the biliary system for more than 6 months can cause this type of cirrhosis.

The etiology of this disease is unknown, which may be related to autoimmune reaction. Autoantibodies and corresponding antigens can form large immune complexes, which can cause immune damage through the complement system. The intralobular bile duct epithelium in portal area may have vacuolar degeneration and necrosis with lymphocyte infiltration, then the small bile duct is destroyed and cholestasis appears, fibrous tissue proliferates and invades and separates the hepatic lobules, and finally develops into cirrhosis.

The appearance of clinical jaundice marks the beginning of jaundice stage. The deepening of jaundice indicates the progress of the disease to the late stage, and the life span is less than 2 years. At this time, osteoporosis, osteomalacia, vertebral compression, and even rib and long bone fractures often occur, which are related to the disorder of vitamin D metabolism. Patients with liver cirrhosis are prone to tracheitis, pneumonia, intestinal infection, spontaneous peritonitis and gram negative bacilli sepsis.

matters needing attention

Liver cirrhosis complicated with intractable ascites for a long time or complicated with infection, the original liver disease aggravation and other factors, appear oliguria, anuria, azotemia, hyponatremia, hyponatremia, the initial kidney often without organic lesions, so it is called functional renal failure, the prognosis of this complication is very poor.