Symptoms of autoimmune hepatitis

summary

Autoimmune hepatitis is a chronic inflammation of liver caused by autoimmune reaction. The changes of liver tissue were consistent with those of chronic viral hepatitis, but the serum viral markers were negative. Let's talk about the symptoms of autoimmune liver disease.

Symptoms of autoimmune hepatitis

The ratio of male to female is 1:4. There are two peaks of onset age of 10-30 years old and above 40 years old. Most of the patients showed chronic hepatitis, about 34% of the patients had no symptoms, only because of abnormal liver function;

30% of the patients had cirrhosis at the time of treatment; 8% of the patients were diagnosed with decompensated cirrhosis such as hematemesis and / or melena; Some patients with acute or even fulminant onset (about 26%), the transaminase and bilirubin levels are high, the clinical process is dangerous.

About 17% ～ 48% of AIH patients have other autoimmune diseases, such as rheumatoid arthritis, thyroiditis, ulcerative colitis, type 1 diabetes, and even some patients first visit.

matters needing attention

The prognosis of AIH is quite different. Patients without treatment can slowly progress to cirrhosis, or develop to acute, subacute, fulminant liver disease, and eventually die of various complications. Retrospective analysis showed that the 3-year and 5-year survival rates of severe AIH patients were 50% and 10%, respectively. After treatment, the 20-year survival rate of the patients was 80%. There was no significant difference between the life span of the patients and the healthy people matched with gender and age. Asymptomatic patients and patients with HLA-DR3 have better prognosis. Early diagnosis and appropriate treatment is an important means to improve the prognosis.