Ankylosing spondylitis?

summary

Ankylosing spondylitis (as) is a disease with the main symptoms of sacroiliac joint and spinal attachment point inflammation. It was strongly associated with HLA-B27. Some microorganisms, such as Klebsiella pneumoniae, have common antigens with their own tissues, which can induce abnormal immune response. It is a chronic inflammatory disease characterized by fibrosis and ossification of large joints of limbs, annulus fibrosus of intervertebral disc and its adjacent connective tissue, and ankylosis of joints. Ankylosing spondylitis belongs to the category of rheumatism. Its etiology is still unclear. It is a chronic disease with the spine as the main lesion site, involving the sacroiliac joint, causing spinal ankylosis and fibrosis, causing varying degrees of eye, lung, muscle and bone lesions. It is an autoimmune disease. What are the new drugs for ankylosing spondylitis?

Ankylosing spondylitis?

1. It is likely to be affected by environmental factors (including infection) on the basis of genetic factors. Genetic factors play an important role in the pathogenesis of as. It is generally believed that HLA-B27 is directly related to HLA-B27, and the incidence rate of AS is 10% to 20%. Immunological factors are also one of the causes. It is found that the complement level of 60%AS patients is increased. Most of the cases have IgA type wet factors, and serum C4 and IgA levels are significantly higher. Trauma, endocrine disorders, metabolic disorders and allergic reactions were also suspected as risk factors.

2. Most of as patients have joint disease, and most of them first invade sacroiliac joint, then ascend to cervical spine. A few patients are invaded by cervical vertebra or several spinal segments at the same time, and can also invade the surrounding joints. In the early stage, there is inflammatory pain in the joints, accompanied by muscle spasm around the joints, and a sense of stiffness, which is obvious in the morning. It can also be manifested as nocturnal pain, which can be relieved by activities or taking analgesics. With the development of the disease, joint pain was alleviated, and the movement of each spinal segment and joint was limited and deformed. In the late stage, the whole spine and lower limbs became rigid and arched, flexing forward.

3. Symphysis pubis can also be involved. The upper edge of pelvis, ischial tubercle, greater trochanter of femur and heel may have osteoarthritis symptoms. In the early stage, local soft tissue swelling and pain, and in the late stage, osteomegaly. General peripheral arthritis can occur before or after spondylitis, local symptoms and rheumatoid arthritis is not easy to distinguish, but less deformity.

matters needing attention

1. It is necessary to avoid heavy load to aggravate the disease. Avoid holding a position for a long time. If you want to sit for a long time, you should get up for at least ten minutes every hour. Do not use the back restraint (it will reduce the activity) to worsen the spondylitis. 2. Avoid pillow and soft bed when sleeping. It's best to lie flat and keep your back upright when you sleep. 3. When you get up in the morning and your back is stiff, you can take a hot bath to improve it. Hot compress can also relieve local pain. Don't smoke to avoid lung injury. 4. Be careful to avoid injury. Be sure to fasten your seat belt when driving and try not to ride a motor vehicle. 5. In cold and humid seasons, it is more important to prevent recurrence of symptoms. 6. Gastrointestinal tract and urinary tract infection often induce spondylitis, so we should pay attention to food hygiene, drink more boiled water, eat more vegetables and fruits, avoid choking urine and constipation. 7. Pay attention to other family members for symptoms of ankylosing spondylitis, such as backache, morning stiffness, etc. If so, seek medical advice as soon as possible.