Nephrotic syndrome symptoms?

summary

Nephrotic syndrome (NS) can be caused by a variety of causes, such as increased glomerular basement membrane permeability, a group of clinical symptoms characterized by massive proteinuria, hypoproteinemia, high edema and hyperlipidemia. Nephrotic syndrome symptoms? Next, I'd like to share my views with you.

Nephrotic syndrome symptoms?

Massive proteinuria is the most important clinical manifestation of NS patients and the most basic pathophysiological mechanism of nephrotic syndrome. Massive proteinuria refers to adult urinary protein excretion > 3.5g/d. Under normal physiological conditions, the glomerular filtration membrane has molecular barrier and charge barrier, resulting in the increase of protein content in the original urine. When it far exceeds the amount of proximal convoluted tubule resorption, a large amount of proteinuria is formed.

Plasma albumin decreased to < 30g / L. In NS, a large amount of albumin is lost from urine, which promotes the compensatory synthesis of albumin in liver and the increase of renal tubular decomposition. Hypoalbuminemia occurs when the increase of albumin synthesis in liver is insufficient to overcome the loss and decomposition. In addition, NS patients with gastrointestinal mucosal edema lead to decreased diet, insufficient protein intake, malabsorption or loss, which is also the cause of aggravating hypoalbuminemia.

Hypoalbuminemia, decrease of plasma colloid osmotic pressure and water entering tissue space from vascular cavity are the basic causes of NS edema. In recent years, studies have shown that about 50% of patients have normal or increased blood volume and normal or decreased plasma renin levels, suggesting that some of the factors that are involved in renal edema and water retention play a role in the pathogenesis of NS * edema.

matters needing attention

Nephrotic syndrome prevention should also prevent the occurrence of infectious diseases such as cold, tonsillitis infection, throat infection. Once suffering from these diseases, timely treatment is needed. Because these infectious diseases will cause the weakening of autoimmune function, making kidney disease worse.