How does retinal degeneration check out?

summary

Retinitis pigmentosa is relatively common in China, and the incidence rate is about 1/2400. The age of onset ranged from 20 to 40 years. Bilateral lesions were symmetrical and developed simultaneously. Male more than female, male to female ratio is 4:1, so let's talk about retinal degeneration how to find out?.

How does retinal degeneration check out?

First, according to the typical fundus changes, the diagnosis of this disease is not difficult. But it should be differentiated from white spot retinal degeneration. White spots with uniform distribution, clear boundary and almost equal size can be seen in the fundus of patients with white macular degeneration; It is quite different from the case of crystal like bright spot concentrated in the posterior pole.

Second: the disease is an autosomal recessive genetic disease associated with primary retinitis pigmentosa, and a few of the patients have a history of close relative marriage. Through linkage analysis, more than 50 pathogenic gene loci were found on several chromosomes. In recent years, 18 of them have been identified by the methods of location cloning and "location candidate genes". The genetic defects of these genes can lead to the variation of the normal structure and function of the outer segment of optic cells, and affect the metabolism of optic cells and pigment epithelial cells; It can also interfere with the interaction between optic cells and pigment epithelial cells; It leads to the abnormal photoelectric conversion pathway; It can also induce apoptosis induced by adjacent cells. Although this high degree of genetic heterogeneity ends in apoptosis, it has different types and processes in clinic.

Third: the eye is gathered by the blood vessels, and the essence and Qi of the viscera nourish the eyes through the meridians. Eye acupuncture therapy originated from the ancient theory of five wheels and eight outlines. The eye is divided into eight areas by the acquired eight trigrams, connecting the five zang organs and six Fu organs inside, checking the shape, color, silk and collaterals outside, and examining the patient's diseases and body conditions. According to the theory of "observing the eye and observing the disease" in Neijing and the principle of syndrome differentiation and treatment on the division of the viscera of the eye, based on the internal relationship between the eye and the meridians and viscera, acupuncture was performed at specific points around the orbit. Through repeated observation and treatment practice, a kind of micro acupuncture treatment was formed.

matters needing attention

1. There is no pigmentation in the fundus, but the optic papilla is waxy yellow white, vascular stenosis, night blindness and typical visual field changes. 2. Central retinitis pigmentosa is not only typical changes of fundus, but also pigmentation or cystic degeneration, even perforation in macular area. Central visual acuity decreased significantly. 3. Unilateral retinitis pigmentosa had typical retinitis pigmentosa in one eye and normal in the other.