Why is throat cancer misdiagnosed?

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Clinically, MPC is easily confused with metastasis and recurrence of malignant tumor and misdiagnosed. If you have this kind of disease, it is very uncomfortable. Although metastatic cancer and multiple primary cancer show new cancer foci in the patient's body, metastatic cancer essentially comes from primary cancer, and its pathological nature is exactly the same as that of primary cancer; MPC is another kind of new cancer focus in cancer patients. The nature of this cancer focus is completely different from that of the original cancer focus. Now I'll talk about the misdiagnosis of throat cancer. Why? Let me tell you this.

Why is throat cancer misdiagnosed?

First, each tumor has its own unique pathological morphology. The tumor sites are separated from each other. The normal mucosal space between the tumors is at least 50px, or the tumors occurring in the same site are located in different sites or organs at an interval of 5 years or more;

Second, new tumors must be excluded as non metastatic and recurrent cancers. Brownson et al. Classified MPC into simultaneous and metachronous according to the time of occurrence of primary tumors. The occurrence of MPC within 6 months belongs to simultaneous MPC, and the occurrence of MPC over 6 months belongs to metachronous MPC. Kimc retrospectively analyzed 3066 patients who underwent radical gastrectomy. The incidence of recurrent cancer was 2.5%, 45.7% of them were concurrent recurrent cancer, and 54.3% of them were heterogeneous recurrent cancer.

Third, the incidence of MPC is different, foreign literature reported that the incidence of MPC is 3.8% - 10.5%, shiraik reported that the incidence of MPC in esophageal cancer patients with radiotherapy is as high as 33.5% (56 / 167); 5% - 3% in China. Domestic reports are obviously lower than foreign reports. The reasons for the differences may be related to the time of publication, region, race, medical level, understanding of MPC and statistical methods. Most of the second primary cancers occurred within 1-3 years after the first primary cancer, and 52.1% of them occurred within 3 years. Haughey et al. Analyzed 24 literatures about repetitive cancer in head and neck cancer patients, and found that repetitive cancer accounted for 14.2% of the confirmed head and neck cancer, and the second primary cancer of head and neck cancer was mainly found in lung, esophagus and urethra.

matters needing attention

In addition, the incidence distribution of synchronous and metachronous recurrent cancers is different. In the jhk study on the incidence of gastric cancer in Korea, it was found that the most common secondary cancers were colorectal cancer, thyroid, lung, kidney and breast. However, at the same time, the distribution of gastric cancer showed different order: head and neck, esophagus, lung, kidney.