What are the symptoms of fixed drug eruption?

summary

A variety of drugs through a variety of different ways into the body and cause skin mucosal reaction, known as drug eruption or drug-induced dermatitis. Drug eruption can be caused not only by oral administration and injection, but also by embolization, buccal tablets, inhalation, enema, gargling and external use (including eye and nose drops). What are the symptoms of fixed drug eruption?

What are the symptoms of fixed drug eruption?

Fixed drug eruption is not uncommon in children with dermatosis. It is difficult for non specialists and inexperienced specialists to diagnose. Clinical manifestations: 1. In the process of cold or fever, one or more round or oval purplish red spots appear on the skin or at the junction of skin and mucous membrane, accompanied by pruritus, and then turn into purplish brown spots, the itching gradually alleviates, and finally does not itch, and the color of the rash is difficult to fade. 2. After taking the medicine, the original spot will appear redness, swelling and itching again. The area of the skin lesions can be further expanded, and new rashes may appear again. After the erythema subsides, the local skin color will be further deepened. 3. The most common sites of skin lesions were the skin of trunk and limbs, and the junction of skin and mucous membrane. 4. Repeated many times, the deeper the color of the rash.

Key points of diagnosis: 1. Single or multiple purplish red spots with pruritus appear during or after taking medicine for fever or cold, and then leave purplish brown spots; 2. Erythema and pruritus appear again at purplish brown spots during or after taking medicine again, and the color is further deepened after fading, and new rashes may also appear.

Differential diagnosis: 1. Ecchymosis after skin collision; 2. Painful ecchymosis syndrome; 3. Skin lesions of allergic purpura. After skin bumping, the color of ecchymosis is easy to fade, and rust color may appear in the spots, which is easy to occur in the bumpy parts of the skin. Painful ecchymosis syndrome is common in adult women, and the spots are often accompanied by rust color, which is easy to subside. Allergic purpura skin lesions are purplish red, prone to occur below the arm, the size of lesions vary greatly.

matters needing attention

The adverse reactions of skin and / or mucous membrane damage caused by drugs used for prevention, diagnosis and treatment, no matter through any way, have the characteristics of acute onset, isolated or several well-defined round or oval edematous erythema, which is called fixed erythema type drug eruption. It is a common disease in dermatology emergency.