How to detect Parkinson's disease

summary

I recently found that my grandfather was very unstable in walking, and he couldn't hold his chopsticks when he ate. And the body is always stiff. I checked some medical books and found that this symptom is likely to be Parkinson's disease. Next, I'll tell you how to detect Parkinson's disease.

How to detect Parkinson's disease

First: routine laboratory examination is generally in the normal range, individual can have hyperlipidemia, diabetes, abnormal ECG and other changes. Blood cerebrospinal fluid examination: the level of dopamine decreased, and the concentration of its metabolite homovanillic acid decreased. The contents of 5-hydroxytryptamine metabolites and - hydroxyindoleacetic acid, dopamine β - hydroxylase, somatostatin and - aminobutyric acid in cerebrospinal fluid were decreased.

Second: brain CT, MRI examination: generally no characteristic findings, elderly patients may have varying degrees of brain atrophy, ventricular enlargement, some patients with cerebral lacunar infarction, individual basal ganglia calcification. Blood cerebrospinal fluid examination: the level of dopamine decreased, and the concentration of its metabolite homovanillic acid decreased. The contents of 5-hydroxytryptamine metabolites and - hydroxyindoleacetic acid, dopamine β - hydroxylase, somatostatin and - aminobutyric acid in cerebrospinal fluid were decreased.

Third: functional imaging. Pet or SPECT and specific radionuclide detection were used. In the early stage of the disease, the activity of D2 dopamine receptor can be detected, including early hypersensitivity (compensatory stage), late hyposensitivity (decompensated stage) and decreased synthesis of dopamine transmitter, which are valuable for early diagnosis, differential diagnosis and monitoring of disease progression.

matters needing attention

Parkinson's disease can be basically diagnosed by CT and some routine examinations. In addition, this disease is particularly common in the elderly. Blood cerebrospinal fluid examination can also determine whether they have Parkinson's disease. After the diagnosis should be treated in time, pay more attention in daily life.