What symptom does liposarcoma relapse have?

summary

Liposarcoma is the most common type of retroperitoneal soft tissue sarcoma, which needs active treatment. Especially in the area around the kidney. Tumor growth is slow, and the tumor volume is often very large when it is found in clinic. As a complex disease, what are the symptoms of liposarcoma recurrence? How can it be?

What symptom does liposarcoma relapse have?

First: well differentiated liposarcoma: including lipomatoid liposarcoma and sclerosing liposarcoma. The former is similar to lipoma in histology, but the size of adipocytes is different. There are fat and mother cells between adipocytes. Inflammation is often not obvious. Sclerosing liposarcoma consists of lipomatous and sclerosing stromal regions.

Second: myxoid liposarcoma: the tumor has an obvious myxoid background, rich in thin-walled branched (chicken claw like) blood vessels. Adipoblasts were mostly star shaped or short spindle shaped. Multinucleated adipoblasts are rare. The typical feature of myxoid liposarcoma cells is the dense staining of tumor nuclei, which is similar to ink spots. Sometimes, the small blood vessels are dilated and densely arranged, and the tumor cell composition is significantly reduced, which is easy to be confused with lymphangioma.

Third: pleomorphic liposarcoma: tumor cell atypia is obvious. Tumor cells or multinucleated tumor cells can be seen with abundant cytoplasm and fat vacuoles.

matters needing attention

Liposarcoma is often dedifferentiated after repeated recurrences, and a smooth muscle or rhabdomyoid differentiation often occurs. When myogenic differentiation is obvious, it is easy to be misdiagnosed as myogenic tumor, but the typical liposarcoma area can always be found by taking more materials. Round cell liposarcoma is mainly differentiated from retroperitoneal lymphoma, neuroblastoma, Ewing's sarcoma, extrarenal nephroblastoma, rhabdoid tumor, neuroendocrine tumor and small round cell tumor.