Symptoms of fat metabolic myopathy

summary

Metabolic myopathy is a group of diseases caused by the abnormal energy supply in muscle cells, which is mainly caused by the abnormal metabolism of glycogen and fat in skeletal muscle, mainly related to the abnormal metabolism of glycogen, lipid or mitochondria and nuclear gene. What are the symptoms of fat metabolic myopathy? Let's talk about it

Symptoms of fat metabolic myopathy

The main clinical manifestation of mitochondrial disease is multisystem disease with brain and muscle involvement, which is more common in children and adolescents. The main manifestation of muscle damage was that skeletal muscle could not tolerate fatigue; The main manifestations of nervous system were extraocular paralysis, stroke, recurrent seizures, myoclonus, migraine, ataxia, mental retardation and optic neuropathy,

Other systemic manifestations include heart block, cardiomyopathy, diabetes, renal insufficiency, pseudo intestinal obstruction and short stature. Lipid metabolic myopathy is common in children and adults. Most of them have a slow onset, mainly involving skeletal muscle. Symmetrical myasthenia of limbs, a few may have mild muscle atrophy. In addition, neck muscle, masticatory muscle, swallowing muscle and tongue muscle can be involved.

Muscle movement a little longer, the phenomenon of weakness increased significantly, and accompanied by muscle pain. The general course of disease is several months to several years. If carnitine deficiency is pathogenic and systemic, it is accompanied by cardiomyopathy and low keto hypoglycemia besides progressive proximal limb skeletal muscle weakness.

matters needing attention

Glycogen metabolic myopathy is treated with a high protein diet, such as 50% carbohydrate, 20% fat and 25% - 30% protein. In the diet of lipid metabolic myopathy, low protein, low fat and high carbohydrate diet is recommended.