Precocious symptoms?

summary

Precocious puberty is a common developmental disorder of endocrine system in pediatrics. It refers to the abnormal disease that girls show secondary sexual development before 8 years old and boys show secondary sexual development before 9 years old. Central precocious puberty (CPP) is due to the hypothalamus in advance increased gonadotropin releasing hormone (GnRH) secretion and release, early activation of gonadal axis function, leading to gonadal development and secretion of sex hormones, so that internal and external genitalia development and secondary sexual characteristics. CPP, also known as GnRH dependent precocious puberty, is a progressive process until the reproductive system matures. Precocious symptoms? Let's talk about it

Precocious symptoms?

Girls are the most common type of precocious puberty. Girls have 9 times of idiopathic precocious puberty as boys, while boys have a higher development rate of central nervous system abnormalities (such as tumors). The clinical characteristics of central precocious puberty are that the sexual development of precocious puberty is similar to that of normal puberty, but the clinical manifestations are quite different, The development speed of symptoms varies. Some of them can stop for a period of development after sexual development to a certain extent. Some of them can develop again after symptoms subside.

In the process of sexual development, both boys and girls are concerned with the rapid growth of height and weight and the acceleration of bone maturation. Because the rapid growth of bone can make the epiphysis fusion earlier, although the early height is higher than that of children of the same age, the adult height is shorter. After puberty, all the children were normal except that their height was shorter than that of the general population.

The sexual development process of peripheral precocious puberty is quite different from the above rules. In boys with precocious puberty, we should pay attention to the size of testis. If testis is more than ml, it indicates central precocious puberty. If testis is not enlarged but masculine, it indicates peripheral precocious puberty, and its androgen may come from adrenal gland. In the course of the disease, only precocious puberty was found in patients with intracranial tumors, but in the later stage, intracranial hypertension and visual field defect were found.

matters needing attention

At present, in terms of drug treatment, the proposed GnRH agonist is the most effective drug for the treatment of true precocious puberty. This drug can down regulate the GnRH receptor on the surface of GnRH cells, reduce the secretion of sex hormones and reduce their biological activity. This is the most effective drug, but this drug is often used in heavier children, Puberty to the four five, or menstruation, these children, only use this.