What are the causes of death from organophosphorus poisoning

summary

When I was playing at a friend's home last month, I accidentally took Methamidophos by mistake, and then I vomited it out, thinking it was OK. But when I came home, I found that I was not feeling well, so I knew it was organophosphorus poisoning, so I went to the hospital for treatment. The doctor said that a little later might lead to death. Today, let me share with you the causes of death caused by organophosphorus poisoning.

What are the causes of death from organophosphorus poisoning

One of the reasons: residual poison absorption: large dosage, long poisoning time, and incomplete gastric lavage or catharsis, not in time, resulting in gastrointestinal residual poison absorption. Too fast reduction of atropine and cholinesterase reactivators, too long interval of medication and too early withdrawal of drugs can make the accumulation of acetylcholine rebound.

The second reason is that the metabolites of organophosphorus pesticides have more toxic effects. After being absorbed by the human body, some organophosphorus pesticides will be oxidized in the liver to produce more toxic substances, which will be stored in the gallbladder. After eating, the gallbladder will contract due to reflex stimulation, and the poison will enter the small intestine with bile, and then be absorbed into the blood to produce rebound phenomenon.

The third reason: organophosphorus pesticide poisoning can also rebound due to the decline of body resistance and metabolic capacity, which makes the decomposition and excretion of poisons difficult. Some organophosphorus pesticides, such as Monocrotophos and Omethoate, are prone to rebound. Because of its long duration in the body, it leads to the rebound of poisoning.

matters needing attention

Most of the organophosphorus pesticides are biotransformed in the liver and excreted by the kidney. The metabolism rate in the human body is very fast. After effective treatment after poisoning, if there are no other symptoms after one month, there is no need to go to the hospital for further treatment.