Can fibrous dysplasia of bone be treated?
summary
Fibrous dysplasia of bone, also known as fibrous dysplasia of bone, may be related to the abnormal development of primordial mesenchyme. Histological examination showed that the lesions were mainly composed of fibrous tissue with different degrees of maturity and new bone tissue. Generally in childhood onset, to children or adolescents when symptoms. Can fibrous dysplasia of bone be treated?
Can fibrous dysplasia of bone be treated?
The clinical symptoms of fibrous dysplasia of bone are local swelling or swelling, pain, deformity, and the course of disease is slow. Patients with bone cyst usually have no obvious symptoms, or only dull pain, intermittent, or ache after exercise. Most of the bone cysts were oval with uniform density; The morphology and internal structure of fibrous dysplasia of bone are various, which can be divided into insect phagocytic type, cystic type, ground glass type, Luffa type and sclerotic type. When the cyst combined with pathological fracture, the bone fragment moved to the cyst cavity; When pathological fracture occurs in fibrous dysplasia, the displacement of bone fragments is not obvious, the formation of callus is less, and nonunion is easy to form.
According to the number of affected bones and the presence or absence of symptoms other than the skeletal system, the patients can be divided into three types: (1) the patients with only one bone involved are of single bone type（ 2) The most common type was multibony type（ 3) In addition to skeletal lesions, there are brown pigmentation of skin, precocious puberty (common in women) and accelerated bone development and maturation. Blood phosphorus, calcium and alkaline phosphatase were normal.
It should be differentiated from other bone expansive cystic lesions, such as giant cell tumor of bone, endophytic chondroma and hemangioma of bone. (1) facial deformation is the main manifestation of the lesions in maxilla and mandible（ 2) The symptoms of sinuses and nasal cavity invasion are similar to those of rhinitis and sinusitis. Nasal congestion and nasal secretions may increase. Severe cases may cause deviation of nasal septum（ 3) The invasion of the bone can cause the symptoms such as local protrusion and deformation of the external auditory canal, otitis media, hearing impairment and facial paralysis（ 4) If it invades the orbit, there may be tears, exophthalmos, displacement, vision loss, diplopia and other symptoms, which are caused by lacrimal passage and eyeball compression（ 5) Alveolar bone invasion can affect the normal occlusion relationship of upper and lower dentition, and sometimes there may be pain in the neck joint when chewing（ 6) Although intracranial invasion is rare, it is harmful to patients because it can cause increased intracranial pressure and nerve invasion.
matters needing attention
There is no specific drug for this disease, only symptomatic treatment. The main cause of this disease is surgical resection, and radiotherapy may induce malignant transformation. In view of the slow clinical progress of the disease, patients with small lesions or asymptomatic can not be operated temporarily, but should be closely followed up. The patients with rapid development of the disease, accompanied by obvious deformity and dysfunction, should be considered as surgical indications.
