Is infantile hepatitis syndrome easy to treat?

summary

Neonatal hepatitis syndrome is caused by a variety of causes. It is a group of clinical syndromes characterized by obstructive jaundice, hepatosplenomegaly, abnormal liver function, and elevated conjugated and unconjugated bilirubin in late neonatal period. Let's share my experience with you.

Is infantile hepatitis syndrome easy to treat?

1. Etiological treatment: 1; ② Sensitive antibiotics were used to control primary bacterial infection; ③ The patients with congenital metabolic abnormalities should be given special diet treatment. The application of hepatitis B immunoglobulin and hepatitis B vaccine in the treatment of HBV infection has a good effect. Acyclovir (acyclovir) can interfere with hsv-dna and inhibit the replication of viral DNA. It is an ideal drug for the treatment of HSV infection. Usage: 5mg / kg each time, intravenous drip, 3 times / D, for 1 week.

2. Nutritional balance should be paid attention to because of the deficiency of calorie, essential fatty acids and fat soluble vitamins due to anorexia and fat malabsorption. Fasting people should have a certain amount of sugar supply every day, but because liver diseases also affect the ability of glucose tolerance, it is not appropriate to have too much sugar. Glucose can be given at the rate of 8-12 mg / (kg · min). The liver absorbs amino acids from the portal blood to synthesize protein. When the liver has diseases, it is appropriate to supply a general amount of protein. Only when the liver is overloaded, can it meet the physiological requirements.

3. Prednisone 2mg / (kg · d) has certain curative effect in some cases, and gradually decreases after the symptoms are obviously improved. Its effect may be in eliminating the swelling of liver cells, alleviating jaundice, and delaying the fibrosis of liver tissue. The course of treatment depends on the clinical situation, generally 4-8 weeks. Attention should be paid to the prevention of other infections. In addition, dexamethasone can also be used. At present, the clinical value of hormone is still controversial.

matters needing attention

(1) Attention should be paid to nutrition balance（ 2) To ensure the daily carbohydrate supply of fasters, glucose can be given at the rate of 8-12 mg / (kg · min)（ 3) Supply normal amount of protein, do not overload. Amino acid infusion (branched chain amino acids: valine, leucine, isoleucine) should be given for metabolism in extrahepatic tissues to promote protein synthesis.