How to identify thalassemia?

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For diseases such as thalassemia, modern medicine can not find a radical cure, but if active treatment, it can still have a good effect. Thalassemia is terrible, and its timely treatment is even more important. How to identify thalassemia? Next, I'd like to share my views with you.

How to identify thalassemia?

Static type α There were no clinical and blood abnormalities in thalassemia patients. The morphology of red blood cells was normal. The content of hbbart in umbilical cord blood was 0.01-0.02 at birth, but disappeared after 3 months. light α Thalassemia patients without anemia or mild anemia, anemia can be aggravated when infected. Mild liver and spleen enlargement or no enlargement. Mild small cell hypochromic anemia. The levels of HBA2 and HbF were normal or slightly lower. The Hb Bart level in cord blood was 0.03-0.14, which disappeared completely at 6 months after birth.

Thalassemia (thalassemia) is due to the defect of globin gene, resulting in the decrease or deletion of globin peptide chain synthesis, resulting in the loss of hemoglobin α Chain / non chain α Chain imbalance, caused by a group of hereditary hemolytic diseases. The main common types of thalassemia are α Poverty and poverty β The south of China is a high incidence area of ground poverty, especially in Guangxi. The carrying rate of ground poverty is the highest in China, and the carrying rate of population is about 20-25%.

Blood routine analysis alone, due to the influence of other factors, there will still be some missed diagnosis of thalassemia carriers, especially in the case of premarital and prenatal examination, which is related to the health of the next generation, more experimental means are needed as a supplement. Conditional hospital, generally will add hemoglobin electrophoresis analysis. Hemoglobin electrophoresis analysis and blood routine analysis have their own advantages and complement each other. The combination of the two can improve the screening rate. The critical value recommended by the International Association for thalassemia by HPLC is HB A2 < 2.5% or HB A2 > 3.5% α The latter is suspicious β The land is poor.

matters needing attention

Vitamin supplement is the same as that of ordinary people. It is given when the doctor thinks it is necessary. Because it is difficult to detect the disease, it is often given iron to replenish blood. Premarital examination: the marriage object should check whether it is thalassemia with cause, if so, pay special attention to prenatal examination.