What are the symptoms of minimal change nephropathy?

summary

Minimal change nephropathy (MCD), also known as minimal change glomerulopathy, is a common pathological type of primary nephrotic syndrome (NS), accounting for 80% - 90% of children's primary ns and 10% - 20% of adults' primary ns. Now let me talk to you about the symptoms of minimal change nephropathy?.

What are the symptoms of minimal change nephropathy?

The first is that the number of male patients is higher than that of females, and that the incidence rate of children is high. The incidence rate of adults is lower than that of children, but the incidence rate of childhood is 60 years old. The typical clinical manifestations of NS were proteinuria > 3.5 g / D, plasma albumin < 30 g / L, edema and hyperlipidemia. Edema is often the first manifestation after the onset of disease, often more serious, serous cavity effusion can appear. Hematuria and hypertension are rare; Hypertension and renal dysfunction were more common in patients over 60 years old.

Second: most patients (about 80% - 90%) are sensitive to glucocorticoid treatment. Generally, diuretic effect begins to appear after 10-14 days of treatment. Proteinuria can turn negative within a few weeks, and human albumin gradually returns to normal, but it is easy to relapse.

Third, the treatment of MCD should be made according to the specific situation of patients. The first choice is glucocorticoid therapy. For patients who are not sensitive to glucocorticoid therapy, the factors that affect the efficacy of glucocorticoid should be excluded and corrected in time. When using hormone combined with other immunosuppressants, we should closely monitor and prevent serious side effects, and consider the relationship between benefits and risk and economic factors.

matters needing attention

Children with chronic kidney disease six don't: don't infection, don't hurt, don't allergic, don't strenuous exercise, don't eat, don't take medicine. The above points can play an important role in preventing the recurrence and aggravation of kidney disease, delaying the progress of the disease and protecting the kidney.