What are the causes of toxic peripheral neuropathy?

summary

Many drugs are neurotoxic and can cause peripheral neuropathy. The ototoxicity of aminoglycoside antibiotics is one of the most serious drug toxic peripheral neuropathy, which can cause severe hearing impairment, and has attracted great attention in the medical field. At present, the number of new drugs is increasing, and the neurotoxic effects of some drugs can not be confirmed in animal experiments. It needs to be closely observed in the process of clinical application, timely found and take appropriate measures to prevent. Let's share my experience with you.

What are the causes of toxic peripheral neuropathy?

Most drugs are chemical poisons, which mainly affect the axoplasmic transport of neurons, leading to the atrophy and degeneration of distal axons, which is called retrograde neuronal degeneration. A few drugs, such as chloroquine, amiodarone and paxillin maleate, can damage Schwann cells and lead to demyelinating peripheral neuropathy. The mechanism of action is that these drugs can inhibit the activity of lysosomal enzymes and affect lipid metabolism.

Physical examination showed that the glove sock like hypoesthesia, deep and shallow feeling were involved. After or at the same time of sensory disturbance, myasthenia, hypotonia and tendon reflex decrease may appear, and a few of them may manifest as simple motor neuropathy.

When peripheral nerve damage is found, the drug should be stopped in time and other kinds of drugs should be used to treat the primary disease. High dose of B vitamins, adenosine triphosphate (ATP), coenzyme A and inosine can promote the repair and functional reconstruction of nerve tissue.

matters needing attention

For the known neurotoxic drugs, vitamin and energy mixture should be added at the beginning of medication to prevent. If isoniazid is combined with vitamin B6, it can avoid peripheral neurotoxicity. The clinical blood drug concentration was detected and the dosage was strictly controlled.