What causes gout?

summary

Gout is a common and complex type of arthritis. It may be the case in all ages. The incidence rate of male is higher than that of female. Gout patients often have sudden joint pain at night, the onset of acute, severe joint pain, edema, swelling and inflammation, pain gradually reduced until disappeared, lasting for several days or weeks. What causes gout? Next, I'd like to share my views with you.

What causes gout?

First, obesity is a risk factor for gout. Obesity not only increases the risk of gout, but also causes gout earlier in obese patients. With the increase of BMI, the incidence of gout increased significantly, and visceral fat was also closely related to the occurrence of gout.

Second, ethanol stimulates the synthesis of lactic acid, which competitively inhibits the excretion of uric acid in renal tubules. Chronic alcohol-related liver disease caused by long-term heavy drinking is related to the increase of insulin level, which can inhibit insulin signaling pathway, increase the risk of insulin resistance, increase uric acid reabsorption and blood uric acid level.

Thirdly, hyperglycemia is a risk factor for Hua. In diabetic patients, purine catabolism is enhanced, uric acid production is increased, and blood uric acid level is increased. Hua can aggravate renal injury, reduce renal uric acid excretion, and further aggravate the occurrence and development of Hua. However, there is no nonlinear correlation between blood glucose and serum uric acid.

matters needing attention

1. Control uric acid - including diet conditioning and taking drugs, drinking more water, eating less high purine food, abstaining from alcohol, taking anti uric acid drugs, effectively controlling uric acid below 350, can greatly reduce the risk of gout attack. 2. Avoid other causes of gout attack, such as excessive fatigue, cold, poor control of hypertension, etc., which may induce gout. We should try our best to control related diseases and avoid gout induced by related causes.