Symptoms of chromosomal abnormalities in pregnancy

summary

In the 1970s and 1980s, it was found that there was a positive relationship between maternal age and fetal chromosomal abnormalities. Therefore, chorionic biopsy or amniocentesis were mainly provided for elderly women. However, chromosomal abnormalities are not the "patent" of elderly women. If "invasive prenatal diagnosis" is only provided to elderly women, young pregnant women will not be protected. Moreover, most pregnant women are under 35 years old. I'll tell you about the symptoms of chromosomal abnormalities in pregnancy.

Symptoms of chromosomal abnormalities in pregnancy

1. The study found that during the 15-20 weeks of pregnancy, some hormonal quantitation in the blood of pregnant women is related to Down's syndrome. Therefore, "Down's screening in mid pregnancy" came into being. It was widely used in the 1990s. Pregnant women of any age can have blood test in mid pregnancy. If they are at high risk, amniocentesis can be performed. In this way, 70% of Down's syndrome can be detected.

2. Large scale studies have also found that some hormonal quantities in pregnant women's blood can also be used for Down's screening. Therefore, during the period of 11 to 13 weeks, the combination of pregnant women's age, hormonal quantities in blood and fetal neck skin thickness has become "Down's screening in early pregnancy", which is called "Oscar" in English for short. It has gradually become popular in the late 2000s. The sensitivity of this "skin test" and "blood test" is 90%.

3. No matter in the second or first trimester of pregnancy, there is a 5% false positive rate in Down's screening, which means that 5% of pregnancies will be labeled as high risk, but the fetus is actually normal The biggest problem of "false positive" is to cause panic. Before Down's screening, pregnant women can only choose "invasive examination" to make a diagnosis, thus increasing the risk of miscarriage.

matters needing attention

The impact of female chromosomal abnormalities on women is very large. In order to avoid the harm of chromosomes, we should regularly check the body and know the situation of the body at any time, because chromosomal abnormalities can easily lead to spontaneous abortion or fetal arrest in the process of pregnancy.