Reserpine poisoning symptoms?

summary

Reserpine, an alkaloid from the roots of Nerium, is mainly used in the treatment of hypertension. It has sedative effect on patients with anxiety, tension and mania. Reserpine is generally taken orally, and can be injected into bone or vein if necessary. Clinically, the commonly used dose is 0.25-0.75mg per day, which can be taken 2-3 times, or 1-2mg intramuscular or intravenous. For mental patients, the initial dose for adults is 0.5mg, which is the maintenance dose. For restless patients, intramuscular injection can be taken, 3-5mg per time, 2-3 times a day.

Reserpine poisoning symptoms?

Poisoning manifestations: nasal congestion, increased gastrointestinal peristalsis, vomiting, abdominal pain, diarrhea, flushing, drowsiness, hyperhidrosis, weakness of limbs, slow heart rate, decrease of body temperature and blood pressure, weakening or disappearance of nerve reflex, coma, deep and slow breathing, blepharoptosis, pupil narrowing, etc.

Symptoms of poisoning: nasal congestion, abdominal pain, diarrhea, flushing, drowsiness, hyperhidrosis, weakness of limbs, slow heart, hypothermia, decreased or disappeared nerve reflex, unconsciousness, deep and slow breathing, ptosis of eyelids, pupil narrowing, etc. respiratory paralysis can be severely punished.

Toxicology: after oral administration, some of them are absorbed and most of them are destroyed in the intestine. It is rapidly destroyed in the body after absorption. Only a small amount of reserpine was found in the urine. Oral reserpine excretes 50% - 60% of urine in 3-4 hours. After a few days, the urine still contained trace amount of urine. The main toxicity of reserpine is the inhibition of central nervous system. Its inhibition of the central nervous system is mainly sedation rather than anesthesia. Therefore, although it sleeps deeply after poisoning, it can mostly wake up. In addition, the inhibition of the vascular motor center and the depletion of norepinephrine reserve in the vascular wall, heart and sympathetic terminals can cause vasodilation, which can cause the decrease of blood pressure. Too much can cause respiratory and circulatory failure.

matters needing attention

1 ∶ 5000 potassium permanganate solution for gastric lavage and magnesium sulfate for catharsis. 2. Intravenous infusion of glucose and sodium chloride. When the blood pressure dropped, m-hydroxyamine (10-15mg) was given intravenously, and norepinephrine was given intravenously when necessary. 3. Give central stimulant, oxygen inhalation and other symptomatic treatment as appropriate.