Can rituximab treat pemphigus

summary

Pemphigus is a serious skin disease, accompanied by abscess, swelling and pain. Attack is relatively slow, it is easy to relapse, the high incidence group is the elderly. It needs Chinese medicine and Western medicine to cooperate with each other. What drug treatment does pemphigus use? Let's talk about whether rituximab can treat pemphigus.

Can rituximab treat pemphigus

First, pemphigus is a chronic, recurrent, severe intraepidermal acantholysis bullous skin disease. There are antibodies against cadherin, a CA [sup] 2 + [/ sup] dependent intercellular adhesion molecule, in the patients. Therefore, there are relaxant blisters on the normal skin or mucosa, and Nissl sign is positive.

Second, rituximab is a monoclonal antibody against B cell CD20 antigen, which has been used to treat a variety of antibody mediated autoimmune diseases. Rituximab can treat pemphigus very well. The combination of rituximab and intravenous immunoglobulin has better effect, but the one-time use price of the drug is similar to that of rituximab, so the hormone is not needed at all.

Third, rituximab is effective in the treatment of pemphigus vulgaris, but it has a certain lag. It may play a role by eliminating the specific pathogenic antibodies in the body. Anti Dsg3 IgG1 may be only a serological marker of the disease. The changes of cytokines reflect the changes of immune characteristics in patients with pemphigus. Rituximab not only affects B cells, but also indirectly affects other immune cells.

matters needing attention

The therapeutic effect of rituximab on pemphigus is better, and it can be combined with other drugs, and the effect will be better. Pemphigus should be found and treated as early as possible. We should often go to the hospital for examination and pay attention to it.