How is infantile hepatic encephalopathy caused?

summary

Hepatic encephalopathy in children, also known as hepatic coma or hepatic brain syndrome, is a syndrome caused by severe acute and chronic liver diseases, based on metabolic disorders and accompanied by complex neuropsychiatric symptoms. Its occurrence and development often marks liver failure with high mortality. Hepatic encephalopathy includes hepatic coma aura, hepatic coma and chronic interstitial hepatic encephalopathy. All kinds of acute and chronic liver diseases can be accompanied by hepatic encephalopathy. How is infantile hepatic encephalopathy caused? Next, I'd like to share my views with you.

How is infantile hepatic encephalopathy caused?

The most common is massive hemorrhage of digestive tract, which is easy to lead to hepatic encephalopathy due to rupture of esophageal varices with collateral circulation in cirrhosis. In severe liver disease complicated with infection, pathogens and toxins damage the liver, aggravate hepatocyte necrosis and dysfunction, and increase endogenous ammonia production due to enhanced metabolism.

When the blood pH increases, the blood ammonia increases, and it is easy to enter the brain cells through the blood-brain barrier. Hypokalemia is prone to alkalosis, which increases the toxicity of ammonia. Therefore, vomiting, diarrhea, diuretics or hormones can promote hepatic coma. Excessive respiratory alkalosis also aggravates ammonia poisoning.

Due to the decrease of liver detoxification function, many drugs, such as acetaminophen, chlorpromazine, sodium diuretic, aluminum chloride, are easy to induce hepatic coma. When there is ascites in liver cirrhosis, a large number of ascites will be released by abdominal puncture, resulting in a sudden decrease of intraperitoneal pressure and a decrease of blood flowing back to the liver due to portal vasodilation, leading to hepatic ischemia and hepatic encephalopathy.

matters needing attention

Enhance resistance and prevent various infections; On diet, avoid too rough, hot food leading to blood vessel rupture and bleeding; Avoid high protein food such as big fish and meat, MSG and vinegar are commonly used in diet, smoke and wine are not allowed; Keep defecation unobstructed, avoid sleeping pills, anesthetics, etc. In case of abnormal behavior, mental disorders and mental changes, they should be sent to the hospital for detailed examination and early treatment.