Giant cell infection symptoms?

summary

Cytomegalovirus infection is a congenital or acquired infection caused by cytomegalovirus (CMV). The clinical manifestation and outcome of cytomegalovirus infection are closely related to the immune function of individuals. Human cytomegalovirus (HCMV) infection in patients with normal immune function is mainly recessive infection, and some of them are mononucleosis like. CMV infection or CMV reactivation caused by blood transfusion (blood products) or organ transplantation may result in single or multiple organ involvement, the most common being interstitial pneumonia, hepatitis, gastroenteritis, retinitis, etc. Ganciclovir can be used to treat cytomegalovirus infection. Giant cell infection symptoms? Let's talk about it

Giant cell infection symptoms?

Some children have obvious symptoms after birth, such as hepatosplenomegaly, persistent jaundice, skin ecchymosis, microcephaly, chorioretinitis, mental retardation and dyskinesia. Any of the above manifestations can exist alone, and can be accompanied by slow growth, irritability, sometimes fever, body temperature from slightly hot to 40 ℃. But because only a small number of children had clinical symptoms at birth, most of them could not be diagnosed. If symptoms appear only a few months to years after birth, they may also show hearing loss, mild neurological symptoms and developmental disorders, which may affect learning. Children with congenital giant cell inclusion body disease can have various congenital malformations, including spasm, bilateral paralysis, epileptic convulsions, optic atrophy, deafness (a few children have deafness), and increased sensitivity to bacterial infection. Although some asymptomatic children with congenital CMV infection have normal physical development, they can still have congenital malformations and hearing impairment, but the incidence and severity are lower than those with symptoms.

This disease is a self limited disease, and its clinical manifestations are generally mild. Although most infants are subclinical infection, the incidence of its symptoms is still higher than that of adults. It is manifested as enlargement of liver, spleen and lymph nodes, rash, bronchitis or pneumonia, and hepatitis. Different from children with congenital infection, the nervous system is rarely invaded. Childhood infection is often acquired through the respiratory tract, often not dominant, but become a long-term carrier, occasionally with persistent hepatitis or interstitial pneumonia.

This disease can also occur in children who have received fresh blood transfusion for many times, and its performance may be similar to infectious mononucleosis, but the heteroagglutination reaction of EB virus capsid antigen and IgM antibody are always negative, which can also cause hemolytic anemia or infectious peripheral neuritis. Most of the adolescents and adults with normal immune function had latent infection after infection, and occasionally had mononucleosis like manifestations (fever, rash, liver function damage, often no angina, negative for heteroagglutination test).

matters needing attention

1. Various antiviral agents such as ganciclovir, anti cytomegalovirus immunoglobulin, interferon and transfer factor can be used. 2. Propoxyguanosine can prevent CMV from spreading. If combined with high titer anti CMV immunoglobulin, it can reduce the mortality of CMV pneumonia complications after bone marrow transplantation. 3. Pay attention to the symptomatic treatment and nursing work, isolate the sick children, and disinfect their excrement.