Can bone marrow bank be transplanted if one site does not match

summary

In order to succeed in bone marrow transplantation, it is necessary to ensure the success of bone marrow matching. So, can one site of bone marrow bank be transplanted? Let's take a look.

Can bone marrow bank be transplanted if one site does not match

First of all: if you want to transplant, you should first do low resolution. If there are 6 low resolution matching points, then do high-resolution matching. Generally, you can do high resolution matching at 8 points. If there are less, it is not ideal. If all the 10 points are the best, the probability of rejection after transplantation will be minimized.

Secondly, in the aspect of HLA matching, HLA-A, HLA-B and HLA-DR matching are mainly carried out. Only the HLA matching of two individuals is identical can hematopoietic stem cell transplantation be carried out. Otherwise, two situations may occur. One is that the immune cells in patients attack the implanted donor cells as "foreign bodies" or "invaders", which is called "transplantation rejection", and the result is transplantation rejection If the transplantation fails, the "hematopoiesis" can not be activated in the patient's body.

Finally: it may be that the donor's hematopoietic cells are transplanted into the patient's body and produce a large number of immunocompetent cells. These cells "turn away from the host" and attack the patient's tissues and cells as "foreign bodies" and "invaders". The tissues and organs most vulnerable to attack are skin, liver and intestinal tract, with rash, jaundice, elevated transaminase, diarrhea and even bloody stools, which is called graft-versus-host Host disease (GVHD), severe can be fatal.

matters needing attention

Pay attention to the resources around you. Contact China bone marrow bank, request China bone marrow bank to use its huge data to find suitable bone marrow. Patients should keep a stable body, light diet, and adjust their attitude.