How does pituitary prolactinoma infect?

summary

Prolactinoma is usually a single hormone secreting adenoma with sparse granules. Prolactinoma is composed of one kind of tumor cells secreting prolactin or growth hormone, or two or more kinds of tumor cells secreting Mixed Multi hormone. Immunohistochemistry and in situ hybridization analysis showed that the cells producing prolactin can also produce growth hormone. So let's share how pituitary prolactinoma is transmitted?.

How does pituitary prolactinoma infect?

First, prolactinomas are usually divided into microadenomas (10 mm). Most female prolactinomas are microadenomas. Male prolactinomas are characterized by older age, larger tumor size, higher prolactin level and invasive growth of tumor.

Second, the diagnosis depends on the exclusion of other causes of hyperprolactinemia and pituitary compression. First, pregnancy is excluded. Second, the role of drugs is excluded through careful medical history inquiry. Third, other functional causes, such as chest wall injury, renal or liver failure, or systemic and metastatic diseases, are excluded through careful medical history inquiry, physical examination, laboratory and radiological examination. 4. Primary hypothyroidism was excluded by TSH measurement.

Third: excluding physiological factors such as pregnancy and drug use, the following examinations should be carried out: 1. Laboratory examination: the plasma PRL level of hyperprolactin can be from only higher than normal to > 10000ng / ml (0 ~ 23ng / ml for normal women and 0 ~ 20ng / ml for normal men). 2. Imaging examination: to determine the size of pituitary gland, If the pituitary gland exceeds the normal size, it may lead to prolactinemia and hyperprolactinemia. MRI is the first choice for pituitary tumor imaging because of its clear imaging.

matters needing attention

1. According to the size and shape of pituitary tumor, the degree of invasion to surrounding tissue and the course of treatment. 2. Correct diagnosis of pituitary adenoma or related sellar lesions. 3. To judge the soft and hard of T pituitary tumor by imaging, tumor type and history. 4. The patient's age, physical condition, whether to require childbearing, etc. 5. What is the hormone level of the patient, whether there are systemic complications and nasal lesions, etc.