Specific drug for myasthenia gravis

summary

The increase of anti AChR antibody in serum and the decrease of effective AChR number caused by the deposition of postsynaptic membrane are the main causes of the disease. As a more complex disease, the specific drug of myasthenia gravis can?

Specific drug for myasthenia gravis

Treatment 1: adrenocortical hormone. Myasthenia gravis is an autoimmune disease. Suprarenal cortical hormone is a commonly used drug in the treatment of autoimmune diseases. At present, high-dose shock therapy, medium dose shock therapy and low-dose maintenance therapy are generally used in the treatment of myasthenia gravis in China. Studies have confirmed that adrenocortical hormone is an inducer of thymocyte apoptosis It can induce thymocyte apoptosis in vivo and in vitro.

Treatment 2: azathioprine, which is a non-specific immunosuppressant, can inhibit the synthesis of DNA, RNA and protein, thereby inhibiting gene replication and T cell activation, playing a role in the treatment of myasthenia gravis. Indications: the dosage of adrenocortical hormone should be reduced; adverse reactions: neutropenia, abnormal liver function, etc. Studies have shown that long-term use of azathioprine can increase the risk of malignant tumor.

Treatment 3: cyclophosphamide. Cyclophosphamide is a compound composed of nitrogen mustard and phosphoramide group. It is a commonly used alkylating agent immunosuppressant in clinic. It can be used for the treatment of various autoimmune diseases. Generally, the symptoms begin to improve within 2 months, and the dosage is reduced and maintained after 5 years. Indications: it is only used for those who are ineffective or intolerable to other mg drugs; adverse reactions: leukopenia, alopecia, hemorrhagic cystitis, etc.

matters needing attention

Here I would like to give you a warm tip: we should also do moderate exercise, exercise, and enhance our physique, but we should not exercise too much. We should pay special attention to patients with myasthenia gravis. If they exercise too much, they will aggravate their symptoms. Therefore, we should choose some sports that are conducive to the recovery of hyperthyroidism according to our own physical conditions, and patients with serious illness or long-term bedridden Can rise of patients, should pay attention to the occurrence of bedsore.